Scientists have found 162 genes that could trigger heart attacks and coronary heart disease. While experts have always known that genes could play a role in heart diseases, more of them emphasize lifestyle. However, the number of genes that could lead to heart diseases could make them take a more balanced approach.
These findings could help develop better treatments
The researchers also identified the two genes responsible for most heart diseases. These were PHACTR1 and CDKN2B. These genes cause problems in the heart’s arterial walls.
Since heart diseases are the most common cause of mortality worldwide, these findings could help experts remedy that. They could create targeted therapies to prevent heart diseases.
According to the Victor Chang Cardiac Research Institute’s executive director and head study author, Jason Kovacic, some of the genes that the team discovered haven’t been investigated as a cause of heart issues.
Kovacic adds that the researchers are happy to find genes that cause heart disease. However, the genes also present a challenge as the researchers still don’t know which ones cause coronary heart disease.
The team also looked into the places these genes would affect an individual. For instance, some genes could raise cholesterol levels, thus affecting the liver. Others could cause blockages to the arteries of the heart.
How researchers conducted the study
For the study, the team gathered 600 coronary heart disease patients and 150 without the disorder. The volunteers were set to undergo a coronary bypass either because of the disease or another reason.
Before the study, the team knew that PHACTR1 caused coronary heart disease. They also linked it with spontaneous coronary artery dissection, intramuscular dysplasia, migraines, and other vascular diseases.
Researchers point out that there are already genetic tests that scan for at-risk groups. However, these tests aren’t often accurate. Most physicians don’t even use them in clinical settings. The team hopes that their findings could make genetic testing for heart disease more straightforward and more applicable in various settings.
The study also gives scientists a better understanding of the causes of coronary heart disease and heart attacks. It also helps them create targeted therapies that could benefit people with these conditions.
