Typically, bladder cancer originates in the lining cells (urothelial cells) of the bladder. The kidneys and the vessels (ureters) that connect the kidneys to the bladder also contain urothelial cells.
More than 82,000 people in the US develop bladder cancer each year, though effective treatment is available for most.
Urothelial cancer can also develop in the kidneys and ureters, but it is significantly more prevalent in the bladder. The majority of bladder malignancies are diagnosed at an early, highly treatable stage. However, even early-stage bladder cancers can recur after receiving successful treatment; therefore, years of follow-up testing are recommended.
Bladder cancer begins when the DNA of bladder cells undergoes alterations, also known as mutations. The DNA of a cell contains instructions that instruct the organism on what to do. The changes instruct the cell to proliferate swiftly and continue living, whereas normally healthy cells would perish. The abnormal cells form a tumor capable of invading and destroying healthy tissues. Over time, the abnormal cells are capable of separating and metastasizing throughout the body. Compare the symptoms of bladder cancer here below and the treatment options available to you in 2023.
Typically, bladder cancer originates in the lining cells (urothelial cells) of the bladder. The kidneys and the vessels (ureters) that connect the kidneys to the bladder also contain urothelial cells.
More than 82,000 people in the US develop bladder cancer each year, though effective treatment is available for most.
Urothelial cancer can also develop in the kidneys and ureters, but it is significantly more prevalent in the bladder. The majority of bladder malignancies are diagnosed at an early, highly treatable stage. However, even early-stage bladder cancers can recur after receiving successful treatment; therefore, years of follow-up testing are recommended.
Bladder cancer begins when the DNA of bladder cells undergoes alterations, also known as mutations. The DNA of a cell contains instructions that instruct the organism on what to do. The changes instruct the cell to proliferate swiftly and continue living, whereas normally healthy cells would perish. The abnormal cells form a tumor capable of invading and destroying healthy tissues. Over time, the abnormal cells are capable of separating and metastasizing throughout the body. Compare the symptoms of bladder cancer here below and the treatment options available to you in 2023.
Different varieties of bladder cells can become malignant. The form of bladder cancer is determined by the type of bladder cell from which the cancer originates. This information is used to determine which treatments may be most effective for you.
The following are types of bladder cancer:
Urothelial carcinoma
• Formerly known as transitional cell carcinoma, urothelial carcinoma occurs in the cells that line the inside of the bladder. When the bladder is full, urothelial cells expand, whereas they contract when the bladder is clear. These same cells line the interior of the ureters and urethra, where malignancies can also develop. In the United States, urothelial carcinoma is the most prevalent form of bladder cancer.
Squamous cell carcinoma
• Chronic irritation of the bladder, such as that caused by an infection or long-term use of a urinary catheter, is associated with squamous cell carcinoma. In the United States, squamous cell bladder carcinoma is extremely uncommon. It is more prevalent in regions of the globe where schistosomiasis, a parasitic infection, is a common cause of bladder infections.
Adenocarcinoma
• Adenocarcinoma originates in the organs that produce secretions in the bladder. Bladder adenocarcinoma is extremely uncommon.
A number of factors, some of which can be avoided are responsible for the onset of bladder cancer. These include the following:
Smoking
• Due to the accumulation of toxic compounds in the urine, smoking cigarettes, cigars, or pipes may increase the risk of bladder cancer. When a person smokes, the body processes the compounds in the smoke and excretes some of them through urine. These hazardous compounds may cause injury to the membrane of your bladder, which may increase your risk of developing bladder cancer.
Age increase in men in particular
• The risk of bladder cancer increases with age. Although it can occur at any age, the majority of individuals diagnosed with bladder cancer are over 55 years old. Men are also proven more probable than women to develop bladder cancer.
Exposition to specific chemicals
• The kidneys play a crucial role in removing hazardous substances from the bloodstream and depositing them in the bladder. It is believed that exposure to certain compounds may increase the risk of developing bladder cancer. Arsenic and chemicals used in the production of dyes, rubber, leather, textiles, and paint have been linked to bladder cancer.
Chronic inflammation of the bladder.
• Chronic or recurrent urinary infections or inflammations (cystitis), such as those that may result from long-term catheterization, may increase the risk of squamous cell bladder cancer. In some regions of the globe, squamous cell carcinoma is associated with chronic bladder inflammation induced by schistosomiasis, a parasitic infection.
The treatment options for bladder cancer depend on a number of factors, such as the type of cancer, the grade of the cancer, and the stage of the cancer, as well as your overall health and treatment preferences.
Treatment for bladder cancer may include:
• Surgical removal of malignancy cells
• Intravesical chemotherapy is used to treat bladder malignancies that are confined to the bladder epithelium but have a high risk of recurrence or progression to a higher stage.
• Chemotherapy for the entire body (systemic chemotherapy), to enhance the likelihood of a cure in a patient undergoing surgery to remove the bladder, or as a primary treatment when surgery is not possible.
• When surgery isn’t an option or isn’t desired, radiation therapy is frequently used as the primary treatment for cancer.
• Immunotherapy, to stimulate the body’s immune system to combat cancer cells in the bladder or elsewhere in the body.
• Targeted therapy, for the management of metastatic cancer when other therapies have failed.
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