Heart disease-related death might have declined among older people, but according to studies death rates in young patients have grown slightly or remained stagnant. To establish what puts young individuals at higher premature coronary heart disease risk, Mayo Clinic and Bringham and Women’s Hospital researchers analyzed over 50 risk factors in over 28,000 women that took part in the Women’s Health Study.
Diabetes women below 55 at risk of CHD
Interestingly, Type II diabetes women under 55 years were more likely to have CHD over the next twenty years, with lipoprotein insulin resistance showing to be a predictive and strong biomarker. The researchers published their findings in JAMA Cardiology. Corresponding author Samia Mora who is Bingham Centre for Lipid Metabolomics said that it is unfortunate that more and more young people are likely to have heart attacks. Mora indicated that when younger people experience a cardiovascular event, it is likely to affect their contribution to society, productivity, and overall quality of life.
Sagar Dugani, Mayo clinic internal medicine practitioner and study co-author, said that prevention is necessary considering most heart disease risk factors are preventable. Dugani said that the study demonstrated the impact that lifestyle has on women’s health, more so younger women.
The study evaluated cardiovascular disease biomarkers
The study analyzed around 50 biomarkers related to cardiovascular disease. Interestingly, commonly used metrics such as cholesterol, low-density lipoprotein, and hemoglobin A1C had a weaker association with onset CHD in women below 55 years relative to LPIR, which is a new insulin resistance metric. LPIR employs weighted lipoprotein measures combination and has to be analyzed in a specialized lab setting. On the other hand LDL, cholesterol was linked with a 40% increase in inset CHD risk in women below 55, with LPIR demonstrating a 600% increase.
Mora said that in healthy women metabolic syndrome, insulin resistance, and type II diabetes were the main premature coronary events contributors. Obese women below 55 had a fourfold increase in coronary events risk, same as those who had hypertension poor smoked. Also, family history and physical inactivity contributed to increased risk.