Research Shows A Less Known Cannabinoid Could Prevent Neurodegeneration in Brain

In Education

CBN, a lesser-known cannabinoid, is gaining attention for its potential in preventing neurodegeneration in aging brains, alongside THC and CBD, more commonly known cannabinoids.

CBN has neuroprotective effect on AD and Parkinson’s disease 

Research from the Salk Institute suggests that a less potent cannabinoid has shown neuroprotective effects in fruit flies. This discovery may lead to potential therapeutic applications for conditions like traumatic brain injury, Alzheimer’s, and Parkinson’s disease.

Approximately 10% of individuals aged 65 and above may experience age-related neurological conditions like Alzheimer’s or Parkinson’s. However, existing treatment options are limited. Recent research explores the potential of CBN to address this issue.

Scientists investigated CBN’s brain-protective properties and developed four CBN-derived compounds with enhanced neuroprotective effects compared to standard CBN. One of these compounds showed promising results in treating traumatic brain injury in a Drosophila fruit fly model. The research team suggests that CBN shows promise for treating neurological disorders, indicating potential for future therapy development.

Research suggests that CBN and its derivatives show promise in treating neurological disorders due to their neuroprotective properties. Professor Pamela Maher highlights the potential of these compounds in therapeutic development, emphasizing their enhanced neuroprotective abilities and drug-like efficacy through chemical modifications.

Many neurological disorders result in neuron death due to malfunctioning mitochondria. CBN prevents this dysfunction, offering neuroprotective effects. However, the specific mechanisms behind CBN’s action and opportunities for enhancement remain unclear.

CBN Offers protection of neurons by influencing mitochondria function

The Salk research team discovered that CBN protects neurons by influencing mitochondrial function against cell death. They utilized academic and industrial methods to enhance this neuroprotective activity. Fragmenting CBN, they identified effective components and created four new chemical analogs. These analogs were then screened for drug potential.

Researchers aimed to find CBN analogs with enhanced ability to penetrate the brain, faster action, and stronger neuroprotective effects than CBN. Zhibin Liang, the study’s lead author, highlighted the discovery of four such analogs with improved medicinal properties, crucial for therapeutic applications. Analog compounds were tested in a fruit fly model of traumatic brain injury, with CP1 showing notable efficacy, leading to the highest survival rates post-injury.

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