Australian researchers have discovered a small molecule that could lead to the development of innovative drugs for bone disorders and obesity. This molecule plays a crucial role in cell sensing of physical pressures like pushing and pulling. It oversees the functionality of sensors vital for a variety of human physiological functions, including the reception of touch by nerve cells in our skin.
Discovery to boost development of peptide –based treatments
The researchers seek to develop drugs capable of modifying the function of sensors by comprehending the function of a specific molecule. This discovery has potential of developing treatments for inflammatory illness, obesity and osteoporosis.
Victor Chang Cardiac Institute researchers utilized Cryo-electron Microscopy to investigate the interaction between a specific protein molecule and PIEZO ion channels. This discovery holds promise for the development of improved peptide-based treatments, following the identification of the protein’s role.
The study’s lead author Dr Charles Cox stated that the molecules are important in providing constant information to the brain like sensing pain and touch as well as recognizing environmental surrounding. Cox explained that the interacting molecule they identified represents a switch that allows regulation of channels that are widely expressed across the body which will be crucial or a wide range of diseases going forward.
Newly discovered molecule could be activated against obesity
According to the researchers, the findings indicate that the switch may be activated against obesity. Enhancement of the activity of particular molecules may deceive the stomach that it is fuller soon than expected.
Dr Cox explained that they expect to enhance engagement within pathways related with strengthen of bones to prevent osteoporosis even in individuals currently dealing with it. Additionally, this approach may have implications for addressing obesity, a significant risk factor for cardiovascular diseases.
When individuals eat, their stomachs expand which prompts activation of molecules communicating with the brain to indicate satiety once the stomach reaches satiety. By amplifying the functionality of these molecules, it could be possible to potentially initiate an illusion of satiety much earlier, simulating the sensation of fullness.
