Recent research from Georgetown University Medical Center highlights that despite significant advancements in mapping the human brain, there remains a notable gap in comprehending its inner mechanisms. Specifically, scientists have discovered abnormal development in a brain region typically linked with movement in children with developmental language impairments, underscoring the complexity of understanding the mind.
Abnormalities in anterior neostriatum are predictors of developmental disorders
Researchers conducted a study on individuals with developmental language disorders, a condition affecting language development, comparable in prevalence to ADHD and dyslexia and more common than autism. The study found brain abnormalities within the anterior neostriatum, located in the basal ganglia, suggesting a specific neural basis for the disorder.
The researchers analyzed 22 studies investigating brain structures in individuals with language impairments. They employed a novel computational approach to identify consistent patterns of abnormalities across these studies. The analysis revealed that the anterior neostriatum exhibited abnormalities in 100 percent of the studies, while fewer abnormalities were observed in other brain regions.
Lead author, Michael T. Ullman, emphasizes the importance of identifying the neural roots of developmental language challenges to raise awareness of this often overlooked disorder. He underscores the need for further research to comprehend precisely how the anterior neostriatum could contribute to these language difficulties.
Professor Ullman suggests that this research underscores the potential efficacy of pharmaceuticals in ameliorating movement deficits arising from basal ganglia dysfunction. Specifically, medications targeting dopamine receptors are highlighted as an illustrative example.
Anomalies in basal ganglia heightens susceptibility to developmental language challenges
Additionally, strategies aimed at promoting the preservation of intact brain structures to offset such abnormalities might offer considerable utility. Furthermore, anomalies within the basal ganglia could potentially emerge as precursory indicators of heightened susceptibility to developmental language difficulties in the future. These preliminary signals could theoretically prompt subsequent diagnostic investigations, potentially expediting early intervention.
Professor Ullman concludes that persistent research endeavors to deepen our comprehension of the neurobiology underpinning developmental language disorders, particularly concerning the involvement of the basal ganglia, hold promise for aiding the numerous affected children.
