According to a recent study, the consumption of three cups of coffee per day may aid in preventing diabetes and controlling obesity. Swedish researchers suggest that no-calorie beverages containing caffeine should be a primary focus of research to combat weight gain and the development of Type 2 diabetes.
Individuals with a genetic predisposition to slow caffeine metabolism have high benefit
The study indicates that individuals with a genetic predisposition to slow caffeine metabolism, resulting in higher levels of the substance in their bloodstream, experience the most significant benefits. Previous studies have established a correlation between drinking three to five cups of coffee daily and decreased chances of developing cardiovascular illness and Type 2 diabetes.
Researchers have prior knowledge regarding the positive effects of the stimulant that leads to an increase in metabolism, reduction in appetite, and promotes fat burning. Ingesting a dose of 100 mg per day can potentially elevate energy expenditure up to 100 calories per day.
The most recent advancement in this field is from researchers at Karolinska Institute, who have revealed that individuals with specific genes who metabolize caffeine at a slower pace tend to experience a rise in their blood caffeine levels. This heightened level of caffeine, in turn, leads to a greater impact on fat-burning and a reduction in their chances of developing Type 2 diabetes.
CYP1A2 and AHR gene variants responsible for caffeine metabolism
In order to arrive at their findings, the research team conducted a thorough examination of prior studies which shed light on the impact of caffeine on the development of Type 2 diabetes and body fat. Additionally, they explored how the correlation between caffeine and the body is influenced by individuals’ genetic composition.
The study primarily focused on two prevalent genetic variants – CYP1A2 and AHR – which determine the rate of caffeine metabolism in the body. The results indicate that individuals who possess a genetic predisposition to slow caffeine metabolism tended to consume lower quantities of the stimulant. Nevertheless, these same individuals had higher levels of caffeine in their bloodstream than those who metabolized it at a faster rate.
